Best Enzyme Cleaner For Dog Urine

Type: Liquid  | Size: 4 quarts | Best For: Carpets, couches, cloth diapers and pails, laundry, garbage cans | Scent: Lime

Biokleen Bac-Out Enzymatic Stain and Odor Remover is an excellent multipurpose cleaning solution that works wonders on stubborn stains and smells from feces, urine, and vomit. It has an ecological composition, with biodegradable and non-toxic ingredients.

This enzyme cleaner isn't only practical but also environmentally friendly. It is made of biodegradable materials and doesn't contain any artificial fragrances, dyes, phosphates, chlorine, ammonia, or brighteners — extremely important if used on items that will have direct contact with the pet, like pet collars, kennels, bedding, carpets, and couches.

It’s one of the best enzyme cleaners, but we don't recommend Biokleen formulation for velvet, silk, wool, linen, suede, or leather.

Tip: Before applying the product to large areas of carpet or floor, test it on a smaller piece to ensure it won't damage the surface.

 What We Like:
• Biodegradable ingredients
• Fast action
• Made in the US

What We Don’t Like:
• May damage some types of fabrics

Reviews from Buyers:
"Inherited a puppy. This has SAVED my carpet & rugs. I’m on my 2nd bottle, but the first lasted a while, with the puppy peeing and pooping indoors nearly every day. It wipes out the stain & the smell. Smushed in poop disintegrates. I use a scrub brush after a few minutes, then stomp on a towel. Frankly, between THIS product & a dog crate, my life is so much better." — Laura W on Amazon.

Type: Spray | Size: 1 quart | Best For: Carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas | Scent: Unscented 

Rocco & Roxie Supply Co. Stain and Odor Eliminator is a reliable solution for combating stubborn pet stains and odors. This product is one of the bestsellers in the category, has excellent customer reviews, and has a certification label from the Carpet & Rug Institute for being safe for all colorfast carpets.

Thanks to its enzyme formulation, this pet odor-neutralizing product is highly versatile. Users have reported remarkable air quality and freshness after using this spray, whether urine, vomit, or other organic odors. It is safe for children and pets and can be used on multiple surfaces, including carpets, upholstery, and wooden floors.

What We Like:
• Works on all types of surfaces
• Easy to use
• Fast acting
• Money-back guarantee
 
What We Don’t Like:
• Costly
• Strong smell
 
Reviews from Buyers:
"I recently got an 8 week old puppy. She had a few accidents before getting the potty training down. I simply blotted the spot to remove most of the liquid. Then I sprayed liberally with the pet spray and let sit for 30 minutes. I then went back to blot up the cleaner up. The puppy did not go back to the original spots as would be normal. This indicates the enzymes worked and removed all urine scent. The scent left behind is a clean, non irritating smell. I did forget to blot the cleaner up once and it left a mark on the carpet. I was able to go back with more cleaner and treat the spot again to remove the second spot. The puppy had diarrhea and it cleared all smell and the strain from that as well. I would recommend this product whole heartedly!" — Customer on Amazon.

Type: Spray | Size: 1 quart |  Best For: Carpets, hard floors, furniture, fabrics, and hard surfaces | Scent: Light citrus

Nature’s Miracle offers a powerful enzyme solution to address serious dog messes. It promises to effectively remove tough stains and odors caused by urine, diarrhea, vomiting, and other bio-based accidents — it works.

Designed to remain effective as long as any bio-based residue is present, it deters the formation of new stains, reducing the likelihood that your dog will urinate in the same spot again.

The formula’s refreshing lemon scent eliminates odors and leaves your home smelling good. Use it safely on carpets, hard floors, furniture, fabrics, microfiber, and more, making it versatile and indispensable. 

What We Like:
• Certified safe for carpets
• Money-back guarantee
 
What We Don’t Like:
• Not suitable for hardwood, leather, suede, silk, porous stone, or ceramic surfaces
 
Reviews from Buyers:
"Nature's Miracle is really a product one needs when house training . The need to remove any residual scents saves your floors and rugs from repeated " accidents' from your dog. This truly is worth the money." — clem on Amazon.

Type: Spray | Size: 22 fluid ounces | Best For: Upholstery, carpet | Scent: Unscented 

The BISSELL professional stain and odor spray was developed for use in Bissell machines, but it can also be used as an enzyme-based household cleaner. The formula has received high praise for its effectiveness in preventing pets from re-soiling in the same place. 

This formulation easily removes stains and eliminates the smell of smoke, pee, and oil odor. Plus, it’s free from heavy metals, optical brighteners, phosphates, and various dyes.
 
What We Like:
• Reliable performance 
• Removes even the toughest stains
• BISSEL runs a pet foundation
 
What We Don’t Like:
 • You may need multiple applications to see the results
 
Reviews from Buyers:
"With 2 dogs and 2 cats, this has been the only product so far that has actually worked for stain removal. Sometimes too good, as the house I purchased already had poor quality carpets and the spots I’ve used this on show the color they were meant to be! Works well on both new and old stains." — Customer on Amazon.

Type: Spray | Size: 1 quart | Best For: Multisurface | Scent: Unscented

Simple Solution Extreme Pet Stain And Odor Remover is an exceptional product for pet owners who want a hassle-free solution to clean their pet’s messes. The product comes in a spray bottle with a user-friendly spray nozzle that ensures convenient application. 

It can be used on a range of surfaces, such as carpets, upholstery, bedding, and fabric, guaranteeing a spotless and hygienic environment.

Simple Solution is a cost-effective solution for cleaning different types of bodily fluids. However, the strong chemical odor could be improved compared to other enzyme cleaners.

What We Like:
• Multisurface application
• Removes stubborn stains with ease

What We Don’t Like:
• Strong chemical smell
 
Reviews from Buyers:
"A necessary purchase if you are a dog owner. Our puppy has peed on our wood floors and many capets and this does wonders. It gets rid of the smell and works very fast. Just buy it!" — Customer on Amazon.

Type: Spray | Size: 0.75 quarts | Best For: Tiles, couch upholstery, carpets, garbage cans, car interiors | Scent: Fresh orange

If you’re struggling to remove stubborn pet odors, the Angry Orange Pet Odor Eliminator could be the solution you’re looking for. Its powerful formula features citrus enzymes and cold-pressed orange oils that naturally neutralize strong pet smells, including those caused by cat or dog urine. 

The best part is that it works on a wide range of indoor and outdoor surfaces, such as carpets, wooden floors, fabrics, and lawns. The only downside is that it comes at a higher price point, which may not suit budget-conscious consumers.

Note: We don't recommend it for areas where pets will have direct contact with it, such as kennels, cages, litter boxes, diapers, bedding, or travel bags.

What We Like:
• Extremely efficient at eliminating foul odors
• Highly versatile
 
What We Don’t Like:
• Steep price
• Weak nozzle

Reviews from Buyers:
"I've purchased this twice.... product itself is great. Removes odor, nice citrus smell. Bought because we have a new puppy... great on hard floors and carpet! BUT..... both bottles came with nozzles that didn't work well... one leaked everytime you shake the bottle, the other nozzle wouldn't bounce back after pressing so you had to manually push it back with your finger.... I just emptied the contents into an empty spray bottle I had... 5 star for the liquid formula, 1 star for the cheap nozzle. The orange bottle does look nice though." — Luis G. on Amazon.

Type: Spray | Size: 1 quart | Best For: Carpets, floors, furniture, clothing | Scent: Natural

One of the standout advantages of BUBBAS Super Strength Enzyme Cleaner is its potent enzyme formula, which is highly effective in tackling tough stains and odors caused by pet accidents, food spills, and other organic messes. 

This cleaner is versatile and effective on various surfaces, including carpets, upholstery, hardwood floors, and concrete. It’s a convenient choice for pet owners who want one cleaning solution for their entire indoor and outdoor home.

What We Like:
 • Suitable for all types of carpets
 • Can be used on concrete and synthetic grass floors
 • Money-back guarantee
 
What We Don’t Like:
 • Costly
 
Reviews from Buyers:
"We have puppies. And you know what comes with that. We are using this on everything. Yup, going through the entire house. It works well. The scent is strong and it would be nice if were more fragrant but if it comes at the cost of making it less effective it's fine. I'll be ordering it by the truck load."— jls on Amazon.

Type: Liquid | Size: 4 quarts | Best For: Multi-purpose | Scent: Lemon

The Eco Strong Outdoor Odor Eliminator is a highly effective and versatile solution for eliminating unpleasant pet odors in outdoor areas. It can be applied to various outdoor surfaces, such as lawns, kennels, patios, decks, and more. 

The best part is that it works quickly without requiring any rinsing, making it a convenient addition to any pet-friendly home. However, the effectiveness of the solution may vary depending on the type and intensity of the odor. 

What We Like:
 • Easy to use
 • Highly effective
 • You can choose an option with a sprayer
 
What We Don’t Like:
 • Only suitable for outdoors
 
Reviews from Buyers:
"We recently did some construction in our yard. We have 2 large dogs and needed to keep them fenced off from the rest of the yard temporarily. After about 6 weeks, the dog urine smell was noticeable! We were really surprised at how well the treatment worked and it’s easy to apply! I bought 2 big bottles thinking it would need more initially, but the first application did the trick. We will buy this again I once we run low!" — Carin Daly on Amazon.