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Does a music video count? There's one sequence in "Smalltown Boy" by Bronski Beat that has this effect on me for some reason. If you know the video you probably know which one I mean...
The final scene of the anime film " wolf children", when the mother is sitting alone, and hears a wolf howling in the distance and realizes that she has lost her son forever..... Heartbreaking. ( got tears in my eyes just thinking of it...)