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In this day and age, on the surface level, it seems like we know a lot about how the world, the human body, and the universe all work. And though we do know quite a bit, there’s still lots of room for scientific progress. Some theories aren’t as solid as you might think, and there are plenty of questions that have researchers puzzled.

Internet users took to an online thread to share what they think are the biggest still-unanswered mysteries that we don’t seem to be close to fully solving yet. Read on to get your creative juices flowing and to think about something bigger than "what should I have for dinner?"

#1

Scientist examining a brain model with brain MRI scans in the background, highlighting unsolved brain mysteries. What consciousness really is. How does meat think?

Emotional-Sherbet735 , Zyanya Citlalli Report

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    #2

    Young woman stretching in bed with pillows and white bedding, reflecting on mysteries we aren’t getting closer to solving Why we dream. Brain runs a midnight movie with zero budget and wild plots. Why?

    PaperLimb , Getty Images Report

    Marnie
    Community Member
    19 hours ago Created by potrace 1.15, written by Peter Selinger 2001-2017

    It's simple: Dreams are when we roll our eyes back into our heads and see what we're thinking (or so I decided when I was 4). It still makes a bit of sense to me :-)

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    #3

    Underwater scene with light rays piercing through dark water, symbolizing mysteries we aren’t getting closer to solving What kind of life lives in our oceans . Current scientific estimates say that we have only discovered 10-25% of marine species.

    Ok-Strawberry488 , Blaque X Report

    Robin Roper
    Community Member
    15 hours ago Created by potrace 1.15, written by Peter Selinger 2001-2017

    When we find out, the next thing would be figuring out how to s***w it up.

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    Though we don’t fully understand why people sleep, there are some solid, quality theories that scientists are working with.

    For example, recent research suggests that the primary purpose of sleep for humans may be to remove toxic and metabolic waste from the brain.

    According to one perspective article, if these toxins are allowed to build up, they might compromise brain functionality.

    Meanwhile, researchers at the Washington University School of Medicine in St. Louis found that during sleep, brain cells propel fluid into, through, and out of the brain, cleaning it of waste.

    “These neurons are miniature pumps. Synchronized neural activity powers fluid flow and removal of debris from the brain. If we can build on this process, there is the possibility of delaying or even preventing neurological diseases, including Alzheimer’s and Parkinson’s disease, in which excess waste – such as metabolic waste and junk proteins – accumulate in the brain and lead to neurodegeneration,” explains neurologist Li-Feng Jiang-Xie, PhD, first author and postdoctoral research associate in the Department of Pathology & Immunology.

    #4

    Vast starry night sky showing cosmic mysteries and space phenomena beyond current human understanding. What the universe, or multi-verse, is inside of. Like where is the end and if there is no end what is it all in? My brain can't handle this, no amount of theories can make me stop wondering.

    Edgeguy13 , Jeremy Thomas Report

    Daisydaisy
    Community Member
    Premium
    11 hours ago Created by potrace 1.15, written by Peter Selinger 2001-2017

    I used to lie awake as a child trying to think about this and just freaking out

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    #5

    Eerie figure wearing sunglasses against a distorted background representing unsolved mysteries and unknown puzzles. Tossing out one less existential, but who pirated the WGN signal with a Max Headroom skit in the 80s.

    Lots of theories, but no real evidence and no one has any idea who did it.

    Kudos to the people involved for actually keeping their mouths shut for 40 years. Makes me think it was one person that did it all on their own. What are the chances of more than one person keeping a lid on that?

    On the one hand, I want the guy(s) who did it to come out and admit it and how they did it. Statute of limitations has to be up right?

    But I get why they don’t. I’m sure the Feds would find some way to convict them of something if they came forward, statute of limitations be d****d.

    non_clever_username , Unknown Report

    nottheactualphoto
    Community Member
    17 hours ago Created by potrace 1.15, written by Peter Selinger 2001-2017

    "Two people can keep a secret, if one of them is dead." - Ben Franklin, or somebody

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    #6

    Person wearing boots and jeans sitting by the water, reflecting on mysteries that remain unsolved and puzzling. Restless legs syndrome (RLS) is a condition that causes a very strong urge to move the legs. The urge to move usually is caused by an uncomfortable feeling in the legs. It typically happens in the evening or at night when sitting or lying down. Moving eases the discomfort for a short time.

    CletusMuckenfuss , Zachary Ferguson Report

    The Other Guest
    Community Member
    20 hours ago Created by potrace 1.15, written by Peter Selinger 2001-2017

    It's super annoying, too, both for the person who has it (me) and the person who shares their bed (Mr OG).

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    “It is critical that the brain disposes of metabolic waste that can build up and contribute to neurodegenerative diseases. We knew that sleep is a time when the brain initiates a cleaning process to flush out waste and toxins it accumulates during wakefulness. But we didn’t know how that happens. These findings might be able to point us toward strategies and potential therapies to speed up the removal of damaging waste and to remove it before it can lead to dire consequences,” notes Jonathan Kipnis, PhD, the senior author on the paper, the Alan A. and Edith L. Wolff Distinguished Professor of Pathology & Immunology, and a BJC Investigator.

    According to Kipnis, if you can enhance the cleaning process in the brain, it would be possible to sleep less and remain healthy.

    “Not everyone has the benefit of eight hours of sleep each night, and loss of sleep has an impact on health.”

    #7

    Spiral galaxy in deep space surrounded by stars, illustrating some of the mysteries we aren’t getting closer to solving. Why the universe exists at all instead of nothing.

    Mound_builder , Arnaud Mariat Report

    Jaya
    Community Member
    19 hours ago Created by potrace 1.15, written by Peter Selinger 2001-2017

    Yes, so weird. But... if nothing existed at all, would be even weirder. I cannot wrap my head around either option.

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    #8

    Model of the human brain showing detailed anatomy, illustrating one of the many mysteries we aren’t getting closer to solving. The brain.


    I have brain cancer, and when I was first diagnosed with it I asked how it happened and my doctor shrugged and told me that they don't really understand how brain cancers develop and that we are just stepping our toes in the door for treatment for it.

    Own_Construction2682 , Robina Weermeijer Report

    Anne Roberts
    Community Member
    16 hours ago Created by potrace 1.15, written by Peter Selinger 2001-2017

    It's a tough diagnosis. I wish you the best of luck in your treatment.

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    #9

    Silhouette of a person standing under a vivid starry sky, representing mysteries we aren’t getting closer to solving. Maybe, the size of the universe.

    Only-Function6630 , Greg Rakozy Report

    Dorothy Smith
    Community Member
    18 hours ago Created by potrace 1.15, written by Peter Selinger 2001-2017

    Webb telescope is seeing even more mysteries as it goes.

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    From your perspective, what are the biggest, most important mysteries that remain unanswered to this very day, dear Pandas? What theories do you personally think most people take for granted, even though there’s still room for research?

    What do you do to stay up-to-date with scientific breakthroughs? Let us know what you think in the comments below.

    #10

    Goofy and Pluto in a classic animated scene, highlighting mysteries that remain unsolved over time. What the hell Goofy is supposed to be, given the existence of Pluto.

    CantTakeMeSeriously , Walt Disney Feature Animation Report

    The Other Guest
    Community Member
    20 hours ago Created by potrace 1.15, written by Peter Selinger 2001-2017

    This isn't a mystery at all: he's a dog. He first appeared in the 1932 cartoon "Mickey's Review," and was originally named Dippy Dog. This was changed to Goofy in 1934, with his first appearance under that name being "Orphan's Benefit." The difference between the two is that Goofy is an anthropomorphic character, and Pluto is not.

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    #11

    Ancient undeciphered symbols and markings representing mysteries we aren’t getting any closer to solving. We don’t seem to be making any headway in deciphering Linear A, the Minoan writing from. Which is kind of odd because there’s a rather big sample size and it’s in a pretty central location whose people and culture influenced a lot of our touchstones today, but there’s really been no progress to speak of.

    emptycagenowcorroded , Evans, Arthur, Sir Report

    Kira Okah
    Community Member
    20 hours ago (edited) Created by potrace 1.15, written by Peter Selinger 2001-2017

    The lack of a big sample size is what is standing in the way. Around 1400 samples, mostly fragmentory and heavily damaged, by comparison Linear B has over 6000. Another reason is that most of those are also quick notes instead of full sentences, and we have zero bilingual references. We have deciphered numerals in Linear A, and have some clue of fractions, and a few are close enough to Linear B to make a guess. Note also that Linear A doesn't encode a known language, we don't know Minoan, and we don't know if all Linear A texts are in the Minoan language.

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    #12

    Ancient stone ruins under a clear blue sky, representing mysteries that we aren’t getting any closer to solving. The Bronze Age Collapse. As a history nerd, it keeps me up at night.

    StoicWolf15 , Andy Hay Report

    Skara Brae
    Community Member
    12 hours ago Created by potrace 1.15, written by Peter Selinger 2001-2017

    Look up "sea peoples" on youtube. Unknown people from the sea (duh) attacked the countries around the eastern Mediterranean, about the same time as a long drought. Only the Egyptian civilization survived.

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    #13

    Close-up of an insect on mossy surface, illustrating natural mysteries that remain unsolved in the environment. How do parasites know how to control the behavior of their hosts? Particularly things like fungus, which don't appear to actually have minds of their own?

    Also, how does something evolve to learn how to do that?

    DeadSuperHero , National Geographic Report

    Luke Branwen
    Community Member
    9 hours ago Created by potrace 1.15, written by Peter Selinger 2001-2017

    Unlike most religions who see God as some kind of magical being, I believe God, or some universal consciousness we may call God, is more akin to a scientist and evolution is their way of creation. And some of their experiments yielded horrifying results 😅

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    #14

    Young woman in a brown sweater sitting on concrete steps, lost in thought, reflecting on unsolved mysteries and puzzles. The placebo effect—how our brains can literally heal the body.

    adamfromonline , Anthony Tran Report

    Nikki Sevven
    Community Member
    18 hours ago Created by potrace 1.15, written by Peter Selinger 2001-2017

    I just read a study where the participants had a DNA analysis, then were asked to think of their favorite relative for 20 minutes every day for one month. At the end of the month, the participants' genetic expression leaned more heavily toward that favorite relative.

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    #15

    Vivid deep space scene showing mysterious cosmic clouds and star clusters in a dark universe, highlighting unsolved mysteries. What was before the big bang.

    Longjumping_Soft1890 , NASA Hubble Space Telescope Report

    Stardust she/her
    Community Member
    8 hours ago Created by potrace 1.15, written by Peter Selinger 2001-2017

    How can a ‘before’ exist before the creation of time itself? Humans are a foolish species to assume that we have the capacity to understand the very fabric of reality when all we were made to do was survive on a planet we were tailored for. Perhaps in a billion years we may have evolved the capacity to understand the universe we live in but not today

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    #16

    Person sleeping peacefully wrapped in a blanket surrounded by pillows, representing mysteries that remain unsolved. What does sleep actually do, and why do we need it? On the surface, it seems obvious, but there seems to be a lack of general consensus on why it's necessary. Some species require very little sleep, some require a lot.

    We can point to anecdotes regarding how different animals do it, and even the benefits that come from sufficient sleep.

    We have some good ideas about what sleep does for the body, along with theories as to why this is a necessity. But in terms of a definitive answer, things seem kind of murky.

    DeadSuperHero , Andrej Lišakov Report

    Robin Roper
    Community Member
    15 hours ago Created by potrace 1.15, written by Peter Selinger 2001-2017

    It is known that sleep is a necessary biological process that allows the body and brain repair, restore, and recharge. During sleep, waste is removed from the brain. Other biological processes occur so all this is what sleep actually does.

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    #17

    Star trails radiating in a night sky, illustrating cosmic mysteries that we aren’t getting closer to solving. If the universe continues to expand, what is it expanding into?

    ThreeRRRs , Casey Horner Report

    Colleen Glim
    Community Member
    20 hours ago Created by potrace 1.15, written by Peter Selinger 2001-2017

    But what is it expanding from? The idea of a humongous ball of nothingness that exploded begs the question, how did it explode?

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    #18

    Illustration of a man’s face representing one of the mysteries that people point out as unsolved and baffling. Who was D.B. Cooper and what happened to him and the money?

    BrilliantHyena , Roy Rose Report

    #19

    Thoughtful man in a blue shirt and red tie reflecting deeply on unsolved mysteries and complex questions. How to reliably prevent or stop hiccups. For such a universal experience, its not terribly well-understood since it happens so infrequently, unpredictably, and for (usually) such a short period of time.

    vonHindenburg , Nicola Barts Report

    Nathaniel He/Him Cis-Het
    Community Member
    20 hours ago Created by potrace 1.15, written by Peter Selinger 2001-2017

    When I had hiccups as a child my mum would say "hiccup again and I will give you £20" . I never managed to get that £20. Not once.

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    #20

    A glowing black hole in space with orbiting objects, illustrating mysterious cosmic phenomena people cannot solve. What really happens if you try to enter a black hole and what’s on the other side? We will likely never know.

    djazzie , Alexander Mils Report

    Marnie
    Community Member
    19 hours ago Created by potrace 1.15, written by Peter Selinger 2001-2017

    A black hole is not actually a hole, so why assume one could "enter" it? The other side is just the other side. Like the other side of our sun from where we're currently located. We do know that we could not currently survive approaching closely to a black hole, because the gravity would stretch us. I think OP is thinking a black hole IS a "worm hole" - that that's a fact, but we just don't know how worm holes work yet.

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    #21

    Mature woman in white robe examining her face in a mirror, reflecting on mysteries and unanswered questions. Why aging affects people so differently.

    Ivory-Fern , Getty Images Report

    Miss Tinker
    Community Member
    20 hours ago Created by potrace 1.15, written by Peter Selinger 2001-2017

    Genetics and lifestyle would play a big part.

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    #22

    Intelligence is a concept we understand. Animals don't know what intelligence is, and yet they might or might not use it. What are some other concepts similar to intelligence that we have no idea exist and we have no way of knowing they exist. It's a big assumption that we can understand everything in the universe using intelligence.

    permacougar Report

    Daisydaisy
    Community Member
    Premium
    10 hours ago Created by potrace 1.15, written by Peter Selinger 2001-2017

    Slime moulds, with no nervous system or anything like a brain, can learn. Our understanding of "intelligence" is perhaps very limited

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    #23

    Our brains and bodies and the exact reasons we do things like yawning.

    Icy_Marionberry_2422 Report

    #24

    A smiling couple posing closely together, capturing a moment amidst unsolved mysteries people continue discussing. Not biggest on a universal or global scale, but locally near Philadelphia, a couple has been missing since 2005 and vanished without a trace. They were at a bar and after leaving were never seen again. Car missing, no activity on phones or credit cards. Just gone. A lot of speculation but so far no leads and it bugs me. If interested just google “missing South St couple Philadelphia”.

    lifeslidesdown , CNN Report

    Pferdchen
    Community Member
    5 hours ago (edited) Created by potrace 1.15, written by Peter Selinger 2001-2017

    Around here, it seems that a lot of missing people drove into a body of water. A lot of multi-decade old cold cases have been solved lately due to drones, satellite imagery and improved sonar devices.

    #25

    Two medical professionals in scrubs and masks preparing anesthesia for a patient amid unsolved medical mysteries. How anesthesia works.... Honestly, no one really knows.

    marcus474 , Getty Images Report

    Ace
    Community Member
    20 hours ago Created by potrace 1.15, written by Peter Selinger 2001-2017

    Not true. It's often stated as such, but it's simply the case that like a lot of d***s we can only drill down to a certain molecular level. There is not real mystery waiting to be solved - they know what it does and how it does it to the level of detail required.

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    Note: this post originally had 39 images. It’s been shortened to the top 25 images based on user votes.